Report Number: CS-TR-97-1599
Institution: Stanford University, Department of Computer Science
Title: Trial Banks: An Informatics Foundation for Evidence-Based
Medicine
Author: PhD, Ida Sim, MD,
Date: December 1997
Abstract: Randomized clinical trials constitute one of our main sources
of medical knowledge, yet trial reports are difficult to
find, read, and apply to clinical care. I propose that
authors report trials both as entries into electronic
knowledge bases - or trial banks - and as text articles in
traditional journals. Trial banks should be interoperable,
and we thus require a shared ontology of clinical-trial
concepts.
My thesis work is the design, implementation, and evaluation
of such an ontology. Using a new approach called competency
decomposition, I show that my ontology design is reasonable,
and that the ontology is competent for three of the four core
tasks of clinical-trials interpretation for a broad range of
trial types. Using this ontology, I implemented a frame-based
trial bank that can be queried dynamically over the World
Wide Web. Clinical researchers successfully used this system
to critique trials in the trial bank.
With the advent of digital publication, we have a window of
opportunity to design our publication systems such that they
support the transfer of evidence from the research world to
the clinic. This dissertation presents foundational work for
an interoperating trial-bank system that will help us achieve
the day-to-day practice of evidence-based medicine.
http://i.stanford.edu/pub/cstr/reports/cs/tr/97/1599/CS-TR-97-1599.pdf